• 围甲北京德比中信主将负民生银行 时越逆转胜陈耀烨 2019-03-18
  • [微笑]商品价格受供需关系影响围绕价值上下波动!房价为什么高?炒作改变了供需关系! 2019-03-18
  • 车俊会见毛里求斯代总统 2019-02-13
  • 我的跟帖出不来,讨论不了,奈何?还以为版主护着我么?! 2019-02-13
  • 网站地图 联系我们搜索内部网English | 中国科学院
    江西11选5开奖结果 所况简介 机构设置 科研队伍 科学研究平台 院地合作 党群园地 国际交流 博士后 研究生教育 科学传播 信息公开
    科研进展
    成果报道
    最新重要论文(影响因子PNAS及以上)
    发表论文数据库
    所级学术报告
    科学成果
    发表论文
    专著
    专利
    获奖
    专题
    所史丛书
    所庆专辑
    建所50周年画册
    现在位置:首页 > 科研进展 > 最新重要论文(影响因子PNAS及以上)
    Coiled-coil 1-mediated fastening of the neck and motor domains for kinesin-3 autoinhibition, PNAS, 21 Nov 2018
    2018-11-22 | 【     】【打印】【关闭

    PNAS, 21 November 2018,DOI:https://doi.org/10.1073/pnas.1811209115

    Coiled-coil 1-mediated fastening of the neck and motor domains for kinesin-3 autoinhibition

    Jinqi Ren, Shuang Wang, Han Chen, Wenjuan Wang, Lin Huo, and Wei Feng

    Abstract

    In kinesin-3, the coiled-coil 1 (CC1) can sequester the preceding neck coil (NC) for autoinhibition, but the underlying mechanism is poorly understood. Here, we determined the structures of the uninhibited motor domain (MD)-NC dimer and inhibited MD-NC-CC1 monomer of kinesin-3 KIF13B. In the MD-NC-CC1 monomer, CC1 is broken into two short helices that unexpectedly interact with both the NC and the MD. Compared with the MD-NC dimer, the CC1-mediated integration of NC and MD not only blocks the NC dimer formation, but also prevents the neck linker (NL) undocking and the ADP release from the MD. Mutations of the essential residues in the interdomain interaction interface in the MD-NC-CC1 monomer restored the MD activity. Thus, CC1 fastens the neck domain and MD and inhibits both NC and NL. This CC1-mediated lockdown of the entire neck domain may represent a paradigm for kinesin autoinhibition that could be applicable to other kinesin-3 motors.

    文章链接://www.pnas.org/content/early/2018/11/21/1811209115

    相关报道://www.m71s.net/kyjz/zxdt/201811/t20181122_5191699.html

     

    评 论
                     江西11选5开奖结果
    版权所有:中国科学院生物物理研究所     京ICP备05002792号 京公网安备 110402500011 号
    地址:北京市朝阳区大屯路15号(100101) 电话:010-64889872
    意见反馈联系人:侯文茹 电子邮件:[email protected]
  • 围甲北京德比中信主将负民生银行 时越逆转胜陈耀烨 2019-03-18
  • [微笑]商品价格受供需关系影响围绕价值上下波动!房价为什么高?炒作改变了供需关系! 2019-03-18
  • 车俊会见毛里求斯代总统 2019-02-13
  • 我的跟帖出不来,讨论不了,奈何?还以为版主护着我么?! 2019-02-13